A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet (Randolph Scott). On board are feisty young widow Nancy Wellington (Gail Patrick) and her toddler, Sonny (Billy Lee), as well as the older Abby Masters (Jan Duggan), who begins a romance with scout Jim Burch (Raymond Hatton). Along the way, the wagon train battles Indians led by Kenneth Murdock (Monte Blue), a trapper who doesn't welcome competition for Oregon's lucrative fur trade.